Statistics

The statistics of phosphorylated sites in the catagorized kinase families

All the 543 kinase genes in human, 558 kinase genes in mouse, 320 kinase genes in rat, which were identified by Manning et al., are categorized by their annotated family or subfamily, including totally 230 kinase families. Because the collection of experimentally verified phosphorylated sites from PhosphoELM and SwissProt involved in various species, the number of phosphorylated sites in each kinase family is calculated in human and other species, as well as the number of phosphorylated proteins. Moreover, the sequence logo of each kinase family is presented by using Weblogo.

No.GroupFamilySubfamilyFamily descriptionKinase memberNumber of phosphosites in humanNumber of phosphosites in mouseNumber of phosphosites in rat
1AGCPKB Protein kinase B AKT1 AKT2 AKT3 136(102) 40(26) 7(7) 
2AGCDMPKROCK Rho Kinase ROCK1 ROCK2 68(36) 20(14) 6(4) 
3AGCDMPKGEK Genghis Khan DMPK1 DMPK2 MRCKa MRCKb 4(4) 0(0) 0(0) 
4AGCDMPKCRIK Citron Rho-interacting kinase CRIK 2(1) 2(1) 0(0) 
5AGCGRKGRK G-protein coupled Receptor Kinase GPRK7 RHOK GPRK6 GPRK5 GPRK4 64(23) 0(0) 3(1) 
6AGCGRKBARK Beta Adrenergic Receptor Kinase BARK1 BARK2 36(15) 1(1) 0(0) 
7AGCMASTMAST Microtubule Associated Serine/Threonine Kinase MAST1 MAST2 MAST3 MAST4 0(0) 0(0) 0(0) 
8AGCMASTMASTL MAST like MASTL 0(0) 0(0) 0(0) 
9AGCNDR Nuclear Dbf2-related kinases NDR1 NDR2 LATS1 LATS2 12(5) 0(0) 0(0) 
10AGCPKA Protein kinase A PKACa PKACb PKACg 465(281) 75(51) 55(34) 
11AGCPDK1 Phosphoinositide-dependent protein kinase PDK1 62(27) 7(5) 4(4) 
12AGCPKC Protein kinase C PKCh PKCa PKCb PKCd PKCe PKCg PKCi PKCt PKCz 707(426) 90(51) 55(36) 
13AGCPKCAlpha Protein kinase C, alpha PKCa PKCb PKCg 368(201) 31(19) 2(2) 
14AGCPKCDelta Protein kinase C, delta PKCd PKCt 89(62) 8(5) 1(1) 
15AGCPKCEta Protein kinase C, eta PKCe PKCh 27(19) 4(3) 2(1) 
16AGCPKCIota Protein kinase C, iota PKCi PKCz 31(23) 2(2) 5(4) 
17AGCPKG Protein kinase G PKG1 PKG2 57(33) 15(7) 3(3) 
18AGCPKN Protein kinase N PKN1 PKN2 PKN3 18(5) 3(1) 0(0) 
19AGCRSKRSK Ribosomal S6 Kinase RSK1 RSK2 RSK3 RSK4 100(69) 14(11) 1(1) 
20AGCRSKp70 p70 subfamily of Ribosomal Specific Kinase p70S6K p70S6Kb 26(15) 2(2) 1(1) 
21AGCRSKMSK Mitogen- and Stress-activated protein Kinase MSK1 MSK2 35(28) 9(6) 0(0) 
22AGCRSKL RSK-like RSKL1 RSKL2 0(0) 0(0) 0(0) 
23AGCRSKR RSK-related SgK494 0(0) 0(0) 0(0) 
24AGCSGK Serum and Glucocorticoid Resposive Kinase SGK SGK2 SGK3 31(16) 3(3) 1(1) 
25AGCYANK Yet Another Novel Kinase YANK1 YANK2 YANK3 0(0) 0(0) 0(0) 
26AtypicalABC1 ABC1 atypical kinases ADCK1 ADCK2 ADCK3 ADCK4 ADCK5 0(0) 0(0) 0(0) 
27AtypicalAlphaAlpha Ancient family of atypical kinases AlphaK1 AlphaK2 AlphaK3 0(0) 0(0) 0(0) 
28AtypicalAlphaeEF2K Eukaryotic Elongation Factor 2 Kinase eEF2K 3(1) 0(0) 0(0) 
29AtypicalAlphaChaK Channel Kinase ChaK1 ChaK2 5(3) 0(0) 0(0) 
30AtypicalBCR Breakpoint Cluster Region kinase BCR ABR 0(0) 0(0) 0(0) 
31AtypicalBRD Bromodomain containing kinases BRDT BRD2 BRD3 BRD4 0(0) 0(0) 0(0) 
32AtypicalFAST  FASTK 0(0) 0(0) 0(0) 
33AtypicalG11  G11(STK19) 0(0) 0(0) 0(0) 
34AtypicalH11  H11 0(0) 0(0) 0(0) 
35AtypicalPDHKPDHK Pyruvate Dehydrogenase Kinase PDHK1 PDHK2 PDHK3 PDHK4 BCKDK 12(5) 3(1) 6(4) 
36AtypicalPDHKBCKDK Branched Chain Ketoacid Dehydrogenase Kinase BCKDK 0(0) 0(0) 2(1) 
37AtypicalPIKKTRRAP TRansactivation/tRansformation-domain Associated Protein TRRAP 0(0) 0(0) 0(0) 
38AtypicalPIKKSMG1  SMG1 0(0) 0(0) 0(0) 
39AtypicalPIKKATM Ataxia telangiectasia mutated ATM ATR 86(52) 10(8) 0(0) 
40AtypicalPIKKDNAPK DNA Protein Kinase DNAPK 37(14) 3(2) 0(0) 
41AtypicalPIKKFRAP FKBP12-rapamycin-associated protein FRAP 23(8) 5(3) 2(2) 
42AtypicalRIO  RIOK1 RIOK2 RIOK3 0(0) 0(0) 0(0) 
43AtypicalTAF1  TAF1 TAF1L 5(2) 0(0) 0(0) 
44AtypicalTIF1 Transcriptional Intermediary Factor TIF1a TIF1b TIF1b TIF1D 0(0) 0(0) 0(0) 
45AtypicalMEKK15  MEKK15 0(0) 0(0) 0(0) 
46AtypicalGTF2F1  GTF2F1 0(0) 0(0) 0(0) 
47AtypicalCol4A3BP  Col4A3BP 0(0) 0(0) 0(0) 
48AtypicalBLVRA  BLVRA 0(0) 0(0) 0(0) 
49AtypicalBAZ  BAZ1A BAZ1B 1(1) 1(1) 0(0) 
50CAMKCAMK-Unique  VACAMKL STK33 0(0) 0(0) 0(0) 
51CAMKCAMK1 CAMK family 1 CaMK1a CaMK1b CaMK1g CaMK1d CaMK4 20(17) 6(6) 12(8) 
52CAMKCAMK2 CAMK family 2 CaMK2a CaMK2b CaMK2g CaMK2d 60(42) 20(14) 27(17) 
53CAMKCAMKLNIM1  NIM1 0(0) 0(0) 0(0) 
54CAMKCAMKLNuaK Novel (Nua) Kinase family NuaK1 NuaK2 7(5) 1(1) 0(0) 
55CAMKCAMKLPASK PAS domain Kinase PASK 5(3) 1(1) 0(0) 
56CAMKCAMKLQIK Qin Induced Kinase QIK QSK SIK 12(8) 5(3) 1(1) 
57CAMKCAMKLSNRK  SNRK 0(0) 0(0) 0(0) 
58CAMKCAMKLMELK Maternal Embryonic Leucine zipper Kinase MELK 5(3) 1(1) 0(0) 
59CAMKCAMKLAMPK AMP-activated protein kinase AMPKa1 AMPKa2 57(33) 32(25) 14(9) 
60CAMKCAMKLCHK1 Checkpoint Kinase 1 CHK1 21(15) 0(0) 1(1) 
61CAMKCAMKLCHK2 Checkpoint Kinase 2 CHK2 17(11) 0(0) 0(0) 
62CAMKCAMKLHUNK Hormonally Upregulated Neu-associated Kinase HUNK 0(0) 0(0) 0(0) 
63CAMKCAMKLLKB  LKB1 21(18) 8(7) 5(5) 
64CAMKCAMKLMARK Microtubule Affinity Regulating Kinase MARK1 MARK2 MARK3 MARK4 27(10) 5(4) 2(1) 
65CAMKCAMKLBRSK BRain Specific Kinase BRSK1 4(4) 3(3) 0(0) 
66CAMKCASK calcium/calmodulin-dependent serine protein kinase CASK 0(0) 0(0) 0(0) 
67CAMKDAPK Death Associated Protein Kinase DAPK1 DAPK2 DAPK3 DRAK1 DRAK2 34(23) 7(7) 4(4) 
68CAMKDCAMKL Doublecortin and CaMK-Like DCLK1 DCLK2 DCLK3 0(0) 1(1) 0(0) 
69CAMKMAPKAPKMAPKAPK MAP Kinase Associated Protein Kinase MAPKAPK2 MAPKAPK3 MAPKAPK5 49(33) 21(13) 1(1) 
70CAMKMAPKAPKMNK MAPK iNtegrating or iNteracting Kinase MNK1 MNK2 3(3) 3(3) 0(0) 
71CAMKMLCK Myosin Light Chain Kinases smMLCK TTN caMLCK skMLCK Sgk085 6(4) 2(1) 3(2) 
72CAMKPHK Phosphorylase Kinase PHKg1 PHKg2 18(7) 0(0) 3(3) 
73CAMKPIM  PIM1 PIM2 PIM3 14(7) 5(4) 2(2) 
74CAMKPKD Protein Kinase D PKD1 PKD2 PKD3 26(19) 10(5) 2(2) 
75CAMKPSK Protein Serine Kinase PSKH1 PSKH2 0(0) 0(0) 0(0) 
76CAMKSgK495  SgK495 0(0) 0(0) 0(0) 
77CAMKTrbl tribbles Trb1 Trb2 Trb3 0(0) 0(0) 0(0) 
78CAMKTrio  Trad Trio SPEG Obscn 0(0) 0(0) 0(0) 
79CAMKTSSK Testis Specific Serine Kinase  TSSK1 TSSK2 TSSK3 TSSK4 SSTK 1(1) 3(3) 0(0) 
80CK1CK1 Cell Kinase 1 CK1a CK1d CK1e CK1g2 CK1g3 CK1a2 CK1g1 87(42) 17(8) 10(4) 
81CK1TTBK Tau Tubulin Kinase TTBK1 TTBK2 4(2) 1(1) 1(1) 
82CK1VRK Vaccinia Related Kinase VRK1 VRK2 VRK3 11(7) 0(0) 0(0) 
83CMGCCDKCDK Cyclin Dependent Kinase CDK4 CDK5 CDK6 CDK8 CDK9 CDK10 CDK11 120(63) 33(25) 11(6) 
84CMGCCDKCDK11  CDK11b 0(0) 0(0) 0(0) 
85CMGCCDKCDK7 Cyclin Dependent Kinase subfamily 7 CDK7 17(11) 2(2) 0(0) 
86CMGCCDKCDC2 Cell Division Control 2 CDC2 CDK2 CDK3 231(117) 46(23) 19(11) 
87CMGCCDKCRK7  CHED CRK7 0(0) 0(0) 0(0) 
88CMGCCDKPCTAIRE  PCTAIRE1 PCTAIRE2 PCTAIRE3 0(0) 1(1) 0(0) 
89CMGCCDKPFTAIRE  PFTAIRE1 PFTAIRE2 0(0) 0(0) 0(0) 
90CMGCCDKPITSLRE  PITSLRE 0(0) 0(0) 0(0) 
91CMGCCDKL Cyclin Dependent Kinase Like CDKL1 CDKL2 CDKL3 CDKL4 CDKL5 0(0) 0(0) 0(0) 
92CMGCCK2 Casein kinase II CK2a1 CK2a2 CK2al-rs 474(236) 27(19) 23(15) 
93CMGCCLK CDC-Like Kinase, involved in splicing CLK1 CLK2 CLK3 CLK4 4(2) 0(0) 0(0) 
94CMGCDYRKPRP4  PRP4 1(1) 0(0) 0(0) 
95CMGCDYRKHIPK Homeodomain Interacting Protein Kinases HIPK1 HIPK2 HIPK3 HIPK4 23(14) 11(8) 2(1) 
96CMGCDYRKDYRK Dual-specificity Tyrosine Regulated Kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4 24(19) 8(8) 1(1) 
97CMGCGSK Gycogen Synthase 3 Kinase GSK3A GSK3B 126(54) 35(17) 2(2) 
98CMGCMAPKMAPK Mitogen Activated Protein Kinase Erk1(MAPK3) Erk2(MAPK1) Erk3(MAPK6) Erk4(MAPK4) Erk5(MAPK7) Erk7(MAPK15) JNK1(MAPK8) JNK2(MAPK9) JNK3(MAPK10) NLK p38a(MAPK14) p38b(MAPK11) p38g(MAPK12) p38d(MAPK13) 575(316) 112(66) 32(21) 
99CMGCMAPKJNK JNK subfamily of MAPK JNK1(MAPK8) JNK2(MAPK9) JNK3(MAPK10) 113(60) 28(15) 6(5) 
100CMGCMAPKp38 p38 subfamily of MAPK p38a(MAPK14) p38b(MAPK11) p38g(MAPK12) p38d(MAPK13) 123(64) 17(12) 5(4) 
101CMGCMAPKERK Extracellular signal-Regulated protein Kinase Erk1(MAPK3) Erk2(MAPK1) Erk3(MAPK6) Erk4(MAPK4) Erk5(MAPK7) Erk7(MAPK15) 339(192) 67(39) 21(12) 
102CMGCMAPKnmo nemo NLK 4(3) 2(2) 1(1) 
103CMGCRCK  MAK MOK ICK 1(1) 0(0) 0(0) 
104CMGCSRPK SR Protein Kinase; phosphorylates SR splicing factors MSSK1 SRPK1 SRPK2 1(1) 0(0) 0(0) 
105NDKNDK  NME1A NME1B NME3 NME4 NME5 NME6 NME7a TXNDC3 TXNDC6 0(0) 0(0) 0(0) 
106OtherAURAur Aurora Kinase AurA AurB AurC 68(34) 12(7) 4(4) 
107OtherAURAurB Aurora Kinase B AurB 35(19) 8(4) 3(3) 
108OtherAURAurA Aurora Kinase B AurA 30(13) 2(2) 0(0) 
109OtherBUB  BUB1 BUBR1 0(0) 0(0) 0(0) 
110OtherBud32  PRPK 1(1) 1(1) 0(0) 
111OtherCAMKKMeta Metazoan-specific family of CAMK (Calcium/Calmodulin Regulated Kinase) Kinase CaMKK1 CaMKK2 4(4) 0(0) 2(2) 
112OtherCDC7 Cell Division Control 7 CDC7 2(1) 0(0) 0(0) 
113OtherHaspin  Haspin 3(3) 3(3) 0(0) 
114OtherIKK I kappa Kinase IKKa IKKb IKKe TBK1 102(35) 9(7) 0(0) 
115OtherIRE Inositol REquiring  IRE1 IRE2 0(0) 0(0) 0(0) 
116OtherMOS  MOS 0(0) 2(1) 0(0) 
117OtherKIS Kinase interacting with stathmin KIS 3(3) 1(1) 0(0) 
118OtherNAK Numb-Associated Kinase MPSK1 GAK BIKE AAK1 4(4) 0(0) 0(0) 
119OtherNEK Mitotic Kinase family, also known as NRK (NimA-Related Kinase, based on Aspergillus NimA) NEK1 NEK2 NEK3 NEK4 NEK5 NEK6 NEK7 NEK8 NEK9 NEK10 NEK11 26(12) 6(2) 2(2) 
120OtherNKF1 New Kinase Family 1 SgK110 SgK069 SBK 0(0) 0(0) 0(0) 
121OtherNKF2 New Kinase Family 2 PINK1 0(0) 0(0) 0(0) 
122OtherNKF3 New Kinase Family 3 SgK269 SgK223 0(0) 0(0) 0(0) 
123OtherNKF4 New Kinase Family 4 CLIK1 CLIK1L 1(1) 0(0) 0(0) 
124OtherNKF5 New Kinase Family 5 SgK307 SgK424 0(0) 0(0) 0(0) 
125OtherNRBP Nuclear Receptor Binding Protein NRBP1 NRBP2 0(0) 0(0) 0(0) 
126OtherOther-Unique  RNAseL SgK396 SgK196 0(0) 0(0) 0(0) 
127OtherPEKGCN2 General Control Non-derepressible GCN2 0(0) 0(0) 0(0) 
128OtherPEKPKR Interferon-induced, double-stranded RNA-activated protein kinase PKR 18(6) 0(0) 0(0) 
129OtherPEKPEK Pancreatic eIF-2alpha Kinase  PEK 1(1) 0(0) 0(0) 
130OtherPEKHRI Heme-Regulated Inhibitor kinase  HRI 2(1) 0(0) 0(0) 
131OtherPLK Polo Like Kinases PLK1 PLK2 PLK3 PLK4 82(44) 6(5) 22(5) 
132OtherSCY1  SCYL1 SCYL2 SCYL3 0(0) 0(0) 0(0) 
133OtherSgK071  SgK071 0(0) 0(0) 0(0) 
134OtherSgK493  SgK493 0(0) 0(0) 0(0) 
135OtherSgK496  SgK496 0(0) 0(0) 0(0) 
136OtherSlob Named after the first member, Drosophila SLOw Borders Slob 0(0) 0(0) 0(0) 
137OtherTBCK TBC domain-containing Kinase TBCK 0(0) 0(0) 0(0) 
138OtherTLK Tousled-Like Kinase TLK1 TLK2 3(3) 0(0) 0(0) 
139OtherTOPK T-cell Originated Kinase, also known as PBK (PDZ domain-binding kinase) PBK 0(0) 0(0) 0(0) 
140OtherTTK  TTK 8(5) 0(0) 0(0) 
141OtherULKULK Unc-51 Like Kinase ULK1 ULK2 ULK3 ULK4 0(0) 0(0) 6(3) 
142OtherULKFused  Fused 0(0) 0(0) 0(0) 
143OtherVPS15  PIK3R4 0(0) 0(0) 0(0) 
144OtherWEE Homologs of yeast Wee1; cell cycle kinase Wee1 Wee1B MYT1 1(1) 3(3) 0(0) 
145OtherWNK With No Lysine kinases. Missing the canonical catalytic lysine, instead using a nearby lysine for catalysis Wnk1 Wnk2 Wnk3 Wnk4 7(4) 4(3) 0(0) 
146OtherCDPK  CDPK 0(0) 0(0) 0(0) 
147OtherPAN3  PAN3 0(0) 0(0) 0(0) 
148PKLFJ  FAM198A FAM198B FAM20A FAM20B FAM20C FJB1 0(0) 0(0) 0(0) 
149RGCRGC Receptor Guanylate Cyclases ANPa ANPb CYGD CYGF HSER 0(0) 0(0) 0(0) 
150STESTE-Unique  COT NIK 6(3) 0(0) 0(0) 
151STESTE11MAP3K MAP3K (MAP kinase kinase kinase) genes, homologous to yeast Ste 11 MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 30(17) 6(5) 0(0) 
152STESTE20PAK p21-Activated protein Kinase PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 102(57) 20(14) 8(8) 
153STESTE20PAKB Class B p21-Activated protein Kinase PAK4 PAK5 PAK6 16(7) 2(2) 2(2) 
154STESTE20PAKA Class A p21-Activated protein Kinase PAK1 PAK2 PAK3 76(45) 18(12) 5(5) 
155STESTE20SLK Ste20-Like Kinase  LOK SLK 5(4) 1(1) 0(0) 
156STESTE20STLK Serine Threonine Like Kinase STLK5 STLK6 STLK6-rs 0(0) 0(0) 0(0) 
157STESTE20TAO Thousand and One Kinase, whose sequence was 1001 AA long. Also known as the SULU family TAO1 TAO3 TAO3 0(0) 0(0) 0(0) 
158STESTE20YSK Yeast SPS1/STE20-like kinase YSK1 MST3 MST4 4(4) 0(0) 0(0) 
159STESTE20KHS Kinase Homologous to STE20 KHS1 KHS2 GCK HPK1 1(1) 0(0) 0(0) 
160STESTE20FRAY  STLK3 OSR1 4(2) 3(2) 1(1) 
161STESTE20MSN misshapen HGK TNIK NRK MINK 7(5) 2(2) 1(1) 
162STESTE20MST Mammalian STE20-like kinase MST1 MST2 35(24) 14(13) 0(0) 
163STESTE20NinaC  MYO3A MYO3B 0(0) 0(0) 0(0) 
164STESTE7MAP2K MAP2K (MAP kinase kinase) genes, homologous to yeast Ste 7 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 78(41) 15(12) 6(4) 
165TKAbl Abelson murine leukemia homolog ABL1(Abl) ABL2(ARG) 67(42) 23(17) 1(1) 
166TKAck Activated Cdc42-associated tyrosine kinase ACK TNK1 5(5) 2(2) 1(1) 
167TKALK Anaplastic Lymphoma Kinase ALK LTK 5(3) 0(0) 0(0) 
168TKAxl  AXL MER TYRO3 4(2) 0(0) 0(0) 
169TKCCK4 Colon Carcinoma Kinase 4 CCK4 0(0) 0(0) 0(0) 
170TKCsk C-SRC kinase CSK CTK 22(11) 3(3) 2(2) 
171TKDDR Discoidin Domain Receptor kinase DDR1 DDR2 3(3) 1(1) 0(0) 
172TKEGFR Epidermal Growth Factor Receptor EGFR ErbB2 ErbB3 ErbB4 119(60) 26(10) 0(0) 
173TKEph Ephrin receptors EphA1 EphA2 EphA3 EphA4 EphA5 EphA6 EphA7 EphA8 EphA10 EphB1 EphB2 EphB3 EphB4 EphB5 EphB6 26(13) 5(4) 0(0) 
174TKFAK Focal Adhesion Kinase FAK PYK2 21(11) 4(4) 0(0) 
175TKFerFer Proto-oncogene tyrosine-protein kinase FER FER 9(6) 6(3) 0(0) 
176TKFerFes Proto-oncogene tyrosine-protein kinase Fes/Fps FES 7(2) 3(2) 0(0) 
177TKFGFR Fibroblast Growth Factor Receptor FGFR1 FGFR2 FGFR3 FGFR4 31(12) 7(2) 0(0) 
178TKInsR Insulin Receptor and associated Kinases INSR IRR 47(16) 4(3) 8(1) 
179TKInsRIGF1R Insulin-like growth factor I receptor IGF1R 12(4) 7(2) 7(1) 
180TKJAKJakA First (active) kinase domain of the dual-domain Janus Kinases JAK1 JAK2 JAK3 58(31) 19(7) 4(3) 
181TKTYKTYK2 Non-receptor tyrosine-protein kinase TYK2 8(5) 2(2) 0(0) 
182TKLmr Lemur Kinase LMR1 LMR2 LMR3 0(0) 0(0) 0(0) 
183TKMetMet Met proto-oncogene tyrosine kinase MET RON 22(4) 12(2) 0(0) 
184TKMusk Muscle-Specific Kinase MUSK 0(0) 0(0) 0(0) 
185TKPDGFRPDGFR Platelet-derived growth factor PDGFRa PDGFRb 27(8) 4(3) 1(1) 
186TKPDGFRFms Platelet-derived growth factor, FMS FMS 2(1) 6(1) 0(0) 
187TKPDGFRFLT3 Fms-Like Tyrosine kinase FLT3 4(1) 0(0) 0(0) 
188TKPDGFRKit Platelet-derived growth factor KIT 5(2) 0(0) 0(0) 
189TKRet Proto-oncogene tyrosine-protein kinase receptor ret RET 21(9) 2(1) 0(0) 
190TKRor Regeneron Orphan Receptors ROR1 ROR2 0(0) 0(0) 0(0) 
191TKRyk Receptor Tyrosine Kinase RYK 0(0) 0(0) 0(0) 
192TKSev Named after Drosophila sevenless, a receptor tyrosine kinase involved in eye cell fate determination ROS 0(0) 0(0) 0(0) 
193TKSrcSRM Proto-oncogene tyrosine-protein kinase SRM SRM 0(0) 0(0) 0(0) 
194TKSrcBLK Proto-oncogene tyrosine-protein kinase BLK BLK 4(2) 0(0) 0(0) 
195TKSrcBrk Proto-oncogene tyrosine-protein kinase BRK BRK 11(5) 1(1) 0(0) 
196TKSrcFgr Proto-oncogene tyrosine-protein kinase FGR FGR 6(5) 4(1) 0(0) 
197TKSrcFyn Proto-oncogene tyrosine-protein kinase FYN FYN 67(40) 17(8) 6(5) 
198TKSrcHCK Proto-oncogene tyrosine-protein kinase HCK HCK 28(14) 2(1) 0(0) 
199TKSrcLck Proto-oncogene tyrosine-protein kinase Lck LCK 71(36) 8(5) 1(1) 
200TKSrcLYN Tyrosine-protein kinase LYN LYN 55(32) 21(12) 6(4) 
201TKSrcSrc Proto-oncogene tyrosine-protein kinase Src SRC 220(111) 34(20) 12(8) 
202TKSrcYES Proto-oncogene tyrosine-protein kinase YES YES 7(4) 2(1) 0(0) 
203TKSrcFrk Fyn-related kinase FRK 1(1) 0(0) 0(0) 
204TKSykSYK Spleen tyrosine kinase SYK 48(22) 14(7) 0(0) 
205TKSykZAP70 70 kDa zeta-associated protein, Syk-related tyrosine kinase ZAP70 25(10) 4(1) 0(0) 
206TKTec Tec protein tyrosine kinase family TXK TEC ITK BMX BTK 43(25) 0(0) 4(1) 
207TKTecBTK Bruton tyrosine kinase BTK 13(7) 0(0) 4(1) 
208TKTecITK IL2-inducible T-cell kinase ITK 13(7) 0(0) 0(0) 
209TKTecTXK Tyrosine-protein kinase TXK TXK TEC 15(10) 0(0) 0(0) 
210TKTie Tunica interna endothelial cell kinase TIE1 TIE2 6(1) 2(2) 0(0) 
211TKTK-Unique  SuRTK106 0(0) 0(0) 0(0) 
212TKTrk Neurotrophin receptor tyrosine kinases TRKA TRKB TRKC 12(3) 8(3) 0(0) 
213TKVEGFR Vascular Endothelial Growth Factor Receptors FLT1 FLT4 FLT3 KDR 17(4) 1(1) 0(0) 
214TKLIRAK IL1 Receptor Associated Kinase IRAK1 IRAK2 IRAK3 IRAK4 7(3) 1(1) 1(1) 
215TKLLISKTESK TEstis Specific Kinase TESK1 TESK2 4(4) 0(0) 0(0) 
216TKLLISKLIMK LIM domain containing kinase LIMK1 LIMK2 5(4) 0(0) 0(0) 
217TKLLRRK Leucine Rich Repeat Kinase LRRK1 LRRK2 1(1) 0(0) 0(0) 
218TKLMLKMLK Mixed Lineage Kinase MLK1 MLK2 MLK3 MLK4 5(4) 0(0) 0(0) 
219TKLMLKLZK Leucine zipper-bearing kinase  LZK DLK 0(0) 0(0) 0(0) 
220TKLMLKZAK Sterile alpha motif and leucine zipper containing kinase AZK ZAK 0(0) 0(0) 0(0) 
221TKLMLKTAK1 Transforming growth factor-β-activated kinase 1 TAK1 0(0) 0(0) 0(0) 
222TKLMLKHH498  HH498 0(0) 0(0) 0(0) 
223TKLMLKILK Integrin Linked Kinase ILK 6(6) 0(0) 0(0) 
224TKLRAFRAF RAF proto-oncogene serine/threonine-protein kinase RAF1 ARAF BRAF 13(7) 1(1) 1(1) 
225TKLRAFKSR Kinase Suppressor of Ras KSR1 KSR2 1(1) 0(0) 0(0) 
226TKLRIPK Receptor Interacting Protein Kinases RIPK1 RIPK2 RIPK3 SgK288 ANKRD3 0(0) 0(0) 0(0) 
227TKLSTKRType1 Serine/Threonine Kinase Receptors; receptors for activin and TGFb ligands. Type 1 TGFbR1 ALK7 ALK1 ALK2 ALK4 BMPR1A BMPR1B 15(6) 0(0) 0(0) 
228TKLSTKRType2 Serine/Threonine Kinase Receptors; receptors for activin and TGFb ligands. Type 2 TGFbR2 BMPR2 MISR2 ACTR2 ACTR2B 14(2) 0(0) 0(0) 
229TKLSTKRTGFbR Serine/Threonine Kinase Receptors; receptors for TGFb ligands TGFbR1 TGFbR2 21(5) 0(0) 0(0) 
230TKLTKL-Unique  MLKL 0(0) 0(0) 0(0)