The kinase complement of the human genome, the kinome, provided a start point for comprehensive investigation of protein phosphorylation. Manning et al. identified 518 protein kinase genes and 106 protein kinase pseudogenes in human (Manning et al., 2002 Science). Most protein kinases contain a conserved catalytic domain belonging to the eukaryotic protein kinase (ePK) superfamily (all other protein kinases are classified as atypical protein kinases, or aPKs). ePKs are classified into 7 major groups, including AGC, CAMK, CK1, CMGC, STE, TK, and TKL, and are subdivided into families, and sometimes subfamilies, based on the sequence of their ePK domains. All 518 human kinases are listed as following, users can clikc into the URL link to investigate the detail information about the kinase and their substrates.