RegPhos is a resource to explore the protein kinase-substrate phosphorylation networks in human and mouse. Protein phosphorylation catalyzed by kinases plays crucial regulatory roles in intracellular signal transduction. With the increasing number of in vivo phosphorylation sites has been identified by mass spectrometry-based proteomics, RegPhos (Nucl. Acids Res., 2011) was developed to construct the human phosphorylation networks between protein kinases and substrates. In this update (RegPhos 2.0), we not only integrate the experimental kinase-substrate phosphorylations from public resources and research articles, but also provide the LC-MS/MS phosphor-peptide dynamic expression data for verifying our newly discovered BCR signaling networks in mouse. The RegPhos 2.0 aims to provide a full investigation of kinase-substrate phosphorylation networks in human and mouse by integrating the information of KEGG metabolic pathways and protein-protein interactions. All of the experimental kinase-substrate data could be downloaded in Download page.

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• Human
• Mouse
• Rat