ADH1B_HUMAN - dbPTM
ADH1B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADH1B_HUMAN
UniProt AC P00325
Protein Name Alcohol dehydrogenase 1B
Gene Name ADH1B
Organism Homo sapiens (Human).
Sequence Length 375
Subcellular Localization Cytoplasm.
Protein Description
Protein Sequence MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2N-acetylserine------MSTAGKVIK
------CCCCCCEEE
27.286391920
23PhosphoserineWEVKKPFSIEDVEVA
EEECCCCCCCEEEEC
33.3324275569
35PhosphotyrosineEVAPPKAYEVRIKMV
EECCCCCEEEEEEEE
22.5324275569
76PhosphoserineEAAGIVESVGEGVTT
HHHCCEEECCCCCEE
25.2422135298
82PhosphothreonineESVGEGVTTVKPGDK
EECCCCCEEECCCCE
36.4122135298
100 N-acetyllysineLFTPQCGKCRVCKNP
EECCCCCCCEECCCC
26.8824888345
111PhosphotyrosineCKNPESNYCLKNDLG
CCCCCCCEEEECCCC
14.402030929
150PhosphotyrosineGTSTFSQYTVVDENA
CCCCCCEEEEECCCC
10.586943069
151PhosphothreonineTSTFSQYTVVDENAV
CCCCCEEEEECCCCE
13.3530814717
179PhosphothreonineLIGCGFSTGYGSAVN
EECCCCCCCCCCEEE
31.9622135298
181PhosphotyrosineGCGFSTGYGSAVNVA
CCCCCCCCCCEEEEE
14.1622135298
213 N-acetyllysineLSAVMGCKAAGAARI
HHHHHCCHHHCCEEE
35.2324889021
247PhosphotyrosineECINPQDYKKPIQEV
CCCCHHHHCHHHHHH
18.7022135298
320PhosphotyrosineRTWKGAVYGGFKSKE
CCCCCCCCCCCCCCC
15.8220561345
331N6-acetyllysineKSKEGIPKLVADFMA
CCCCCHHHHHHHHHH
54.3927178108
339 N-acetyllysineLVADFMAKKFSLDAL
HHHHHHHHHCCHHHH
42.437666867
340N6-acetyllysineVADFMAKKFSLDALI
HHHHHHHHCCHHHHH
30.5527178108
342PhosphoserineDFMAKKFSLDALITH
HHHHHHCCHHHHHHH
33.9320166139
355N6-acetyllysineTHVLPFEKINEGFDL
HHCCCHHHHCCCCCE
51.7320167786
365PhosphoserineEGFDLLHSGKSIRTV
CCCCEECCCCCCEEE
48.1320166139
367 N-acetyllysineFDLLHSGKSIRTVLT
CCEECCCCCCEEEEE
45.8024885157

Disease-associated PTM Sites based on nsSNP

* Distance = the distance between SNP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SNP Related Disease Reference
2Acetylation8 (6)HP;Rrs1229984
  • Esophageal cancer:esophageal carcinoma
  • Oral cavity and pharyngeal cancer:upper aerodigestive tract neoplasm
  • Alcohol dependence:alcohol dependence
  • Alcohol consumption:alcohol drinking
  • Oral cavity and pharyngeal cancer:pharynx cancer, oral cavity cancer
  • Oral cavity cancer:oral cavity cancer
19698717
21437268
23456092
23743675
27749845
28485404
28135244
28892062
24166409
320Phosphorylation330 (10)RCrs2066702
  • Alcohol dependence:alcohol dependence
  • Alcohol dependence:alcohol dependence measurement
24166409
331Acetylation330 (1)RCrs2066702
  • Alcohol dependence:alcohol dependence
  • Alcohol dependence:alcohol dependence measurement
24166409
339Acetylation330 (9)RCrs2066702
  • Alcohol dependence:alcohol dependence
  • Alcohol dependence:alcohol dependence measurement
24166409
340Acetylation330 (10)RCrs2066702
  • Alcohol dependence:alcohol dependence
  • Alcohol dependence:alcohol dependence measurement
24166409
365Phosphorylation370 (5)RCrs2066702
  • Alcohol dependence:alcohol dependence
  • Alcohol dependence:alcohol dependence measurement
24166409
367Acetylation370 (3)RCrs2066702
  • Alcohol dependence:alcohol dependence
  • Alcohol dependence:alcohol dependence measurement
24166409

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYOME_HUMANPDE4DIPphysical
21988832
RACK1_HUMANGNB2L1physical
21988832
AACT_HUMANSERPINA3physical
21988832
PML_HUMANPMLphysical
21988832
IRAK3_HUMANIRAK3physical
21988832

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00898Ethanol
DB01213Fomepizole
Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Human liver alcohol dehydrogenase. 1. The primary structure of thebeta 1 beta 1 isoenzyme.";
Hempel J., Buhler R., Kaiser R., Holmquist B., de Zalenski C.,von Wartburg J.-P., Vallee B.L., Joernvall H.;
Eur. J. Biochem. 145:437-445(1984).
Cited for: PROTEIN SEQUENCE OF 2-375.

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