ADH1B_HUMAN - dbPTM
ADH1B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADH1B_HUMAN
UniProt AC P00325
Protein Name Alcohol dehydrogenase 1B
Gene Name ADH1B
Organism Homo sapiens (Human).
Sequence Length 375
Subcellular Localization Cytoplasm.
Protein Description
Protein Sequence MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2N-acetylserine------MSTAGKVIK
------CCCCCEEEE
27.286391920
23PhosphoserineWEVKKPFSIEDVEVA
EECCCCEEEEEEECC
33.3324275569
35PhosphotyrosineEVAPPKAYEVRIKMV
ECCCCCCCEEEEEEE
22.5324275569
76PhosphoserineEAAGIVESVGEGVTT
CEEEEEEEECCCCCC
25.2422135298
82PhosphothreonineESVGEGVTTVKPGDK
EEECCCCCCCCCCCE
36.4122135298
100 N-acetyllysineLFTPQCGKCRVCKNP
EECCCCCCCCCCCCC
26.8824888345
111PhosphotyrosineCKNPESNYCLKNDLG
CCCCCCCCCCCCCCC
14.402030929
150PhosphotyrosineGTSTFSQYTVVDENA
CCCCEEEEEEECHHH
10.586943069
151PhosphothreonineTSTFSQYTVVDENAV
CCCEEEEEEECHHHE
13.3530814717
179PhosphothreonineLIGCGFSTGYGSAVN
HHCCHHHHHHHHHHH
31.9622135298
181PhosphotyrosineGCGFSTGYGSAVNVA
CCHHHHHHHHHHHHC
14.1622135298
213 N-acetyllysineLSAVMGCKAAGAARI
HHHHHHHHHCCCCEE
35.2324889021
247PhosphotyrosineECINPQDYKKPIQEV
EEECCCCCHHHHHHH
18.7022135298
320PhosphotyrosineRTWKGAVYGGFKSKE
EEEEEEEECCCCCHH
15.8220561345
331N6-acetyllysineKSKEGIPKLVADFMA
CCHHHHHHHHHHHHH
54.3927178108
339 N-acetyllysineLVADFMAKKFSLDAL
HHHHHHHCCCCCCEE
42.437666867
340N6-acetyllysineVADFMAKKFSLDALI
HHHHHHCCCCCCEEE
30.5527178108
342PhosphoserineDFMAKKFSLDALITH
HHHHCCCCCCEEEEE
33.9320166139
355N6-acetyllysineTHVLPFEKINEGFDL
EEEECHHHHHHHHHH
51.7320167786
365PhosphoserineEGFDLLHSGKSIRTV
HHHHHHHCCCCEEEE
48.1320166139
367 N-acetyllysineFDLLHSGKSIRTVLT
HHHHHCCCCEEEEEE
45.8024885157

Disease-associated PTM Sites based on nsSNP

* Distance = the distance between SNP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SNP Related Disease Reference
365Phosphorylation370 (5)RCrs2066702Alcohol dependence: alcohol dependence24166409
365Phosphorylation370 (5)RCrs2066702Alcohol dependence: alcohol dependence measurement24166409
367Acetylation370 (3)RCrs2066702Alcohol dependence: alcohol dependence24166409
367Acetylation370 (3)RCrs2066702Alcohol dependence: alcohol dependence measurement24166409

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYOME_HUMANPDE4DIPphysical
21988832
RACK1_HUMANGNB2L1physical
21988832
AACT_HUMANSERPINA3physical
21988832
PML_HUMANPMLphysical
21988832
IRAK3_HUMANIRAK3physical
21988832

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00898Ethanol
DB01213Fomepizole
Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Human liver alcohol dehydrogenase. 1. The primary structure of thebeta 1 beta 1 isoenzyme.";
Hempel J., Buhler R., Kaiser R., Holmquist B., de Zalenski C.,von Wartburg J.-P., Vallee B.L., Joernvall H.;
Eur. J. Biochem. 145:437-445(1984).
Cited for: PROTEIN SEQUENCE OF 2-375.

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