ADA30_HUMAN - dbPTM
ADA30_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADA30_HUMAN
UniProt AC Q9UKF2
Protein Name Disintegrin and metalloproteinase domain-containing protein 30
Gene Name ADAM30
Organism Homo sapiens (Human).
Sequence Length 790
Subcellular Localization Late endosome membrane
Single-pass type I membrane protein .
Protein Description Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation. [PubMed: 27333034]
Protein Sequence MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRPKAKSVKKQKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
251 N-acetyllysineVRMRIHLKALEVWTD
CCCEEEEEEEEEECC
36.447710597
685PhosphoserineLRGAIPSSIWVVSII
CCCCCCCCCEEEEHH
18.3446159079
746PhosphothreonineTVQEESKTKTGQEES
EECCCCCCCCCHHHH
43.0268696175

Disease-associated PTM Sites based on nsSNP

* Distance = the distance between SNP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SNP Related Disease Reference
746Phosphorylation737 (9)TArs35273427Breast cancer: breast carcinoma29059683

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SC11C_HUMANSEC11Cphysical
28514442
FOXF2_HUMANFOXF2physical
28514442
SEM6A_HUMANSEMA6Aphysical
28514442
CALX_HUMANCANXphysical
28514442
UBP30_HUMANUSP30physical
28514442
MTF2_HUMANMTF2physical
28514442
SPCS2_HUMANSPCS2physical
28514442
ATS2_HUMANADAMTS2physical
28514442
PLXA2_HUMANPLXNA2physical
28514442
MET7B_HUMANMETTL7Bphysical
28514442
LCLT1_HUMANLCLAT1physical
28514442

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Related Literatures of Post-Translational Modification

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