ACHB4_HUMAN - dbPTM
ACHB4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACHB4_HUMAN
UniProt AC P30926
Protein Name Neuronal acetylcholine receptor subunit beta-4
Gene Name CHRNB4
Organism Homo sapiens (Human).
Sequence Length 498
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein. Cell membrane
Multi-pass membrane protein.
Protein Description After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane..
Protein Sequence MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
76PhosphothreonineNEREQIMTTNVWLKQ
CCEEEEEEEEEEEEE
19.4922135298
26074081
77PhosphothreonineEREQIMTTNVWLKQE
CEEEEEEEEEEEEEE
15.4726074081
88PhosphotyrosineLKQEWTDYRLTWNSS
EEEEEEECCCCCCCC
10.5126074081
282PhosphoserineTFFLLLISKIVPPTS
HHHHHHHHHHCCCHH
19.1222135298

Disease-associated PTM Sites based on nsSNP

* Distance = the distance between SNP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SNP Related Disease Reference
88Phosphorylation91 (3)TIrs12914008Attention function in attention deficit hyperactive disorder: attention deficit hyperactivity disorder, attention function measurement26174813

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBQL1_MOUSEUbqln1physical
16091357

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Related Literatures of Post-Translational Modification

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