ACADS_HUMAN - dbPTM
ACADS_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACADS_HUMAN
UniProt AC P16219
Protein Name Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Gene Name ACADS
Organism Homo sapiens (Human).
Sequence Length 412
Subcellular Localization Mitochondrion matrix.
Protein Description Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms..
Protein Sequence MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
10PhosphoserineAALLARASGPARRAL
HHHHHHHHCHHHHHH
39.49101544929
51N6-acetyllysineTCRDFAEKELFPIAA
HHHHHHHHCHHCHHH
57.1825038526
72N6-acetyllysineLFPAAQVKKMGGLGL
CCCHHHHHHCCCCCE
25.592418873
121PhosphoserineVIMSVNNSLYLGPIL
EEEEECCEEECCCCC
17.1246157401
129N6-acetyllysineLYLGPILKFGSKEQK
EECCCCCCCCCHHHH
48.6925038526
136N6-acetyllysineKFGSKEQKQAWVTPF
CCCCHHHHHEEEECC
42.9725038526
148N6-acetyllysineTPFTSGDKIGCFALS
ECCCCCCEEEEEEEC
44.5225038526
219PhosphothreonineAFLVPMPTPGLTLGK
EEEEECCCCCCCCCC
24.60110741841
262N6-acetyllysineGEPGMGFKIAMQTLD
CCCCCCHHHEEECCC
24.6725038526
305PhosphothreonineMAFGAPLTKLQVIQF
CCCCCCCCHHHHHHH
28.7535103603
306N6-acetyllysineAFGAPLTKLQVIQFK
CCCCCCCHHHHHHHH
44.6020167786
25953088
27178108

Disease-associated PTM Sites based on nsSNP

* Distance = the distance between SNP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SNP Related Disease Reference
219Phosphorylation209 (10)GSrs1799958
  • Serum metabolite ratios in chronic kidney disease:chronic kidney disease, serum metabolite measurement
29545352

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IRF7_HUMANIRF7physical
21988832
CLIC4_HUMANCLIC4physical
26344197
DPEP1_HUMANDPEP1physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
201470Acyl-CoA dehydrogenase short-chain deficiency (ACADSD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB03147Flavin adenine dinucleotide
Related Literatures of Post-Translational Modification

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