ACADL_HUMAN - dbPTM
ACADL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACADL_HUMAN
UniProt AC P28330
Protein Name Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Gene Name ACADL
Organism Homo sapiens (Human).
Sequence Length 430
Subcellular Localization Mitochondrion matrix.
Protein Description
Protein Sequence MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
28PhosphoserineQLPAARCSHSGGEER
CCCCCCCCHHHHHHH
18.35101544913
30PhosphoserinePAARCSHSGGEERLE
CCCCCCHHHHHHHCC
32.00101544921
42N6-acetyllysineRLETPSAKKLTDIGI
HCCCCHHHHCCCCCC
53.2920203611
155N6-acetyllysineHGSEEQIKHFIPQMT
CCCHHHHHHHHHHHH
31.9620203611
162PhosphothreonineKHFIPQMTAGKCIGA
HHHHHHHHCCCCCEE
27.3246157371
189N6-acetyllysineQGIKTNAKKDGSDWI
HHCEEEEEEECCEEE
54.1620167786
20203611
240N6-acetyllysineFLVENGMKGFIKGRK
EEEECCCCCEEECCC
52.6620203611
254N6-acetyllysineKLHKMGLKAQDTAEL
CCCCCCCCCCCCCEE
37.9720203611
271PhosphoserineEDIRLPASALLGEEN
EEEEEEHHHHCCCCC
19.9450563019
318N6-acetyllysineRNYVKQRKAFGKTVA
HHHHHHHHHHHHHHH
45.6420203611
322N6-acetyllysineKQRKAFGKTVAHLQT
HHHHHHHHHHHHCHH
33.1120203611
329PhosphothreonineKTVAHLQTVQHKLAE
HHHHHCHHHHHHHHH
28.6146157377
358N6-acetyllysineCLQLHEAKRLDSATA
HHHHHHCCCCCHHHH
50.9720203611
402PhosphotyrosineEYPIAKAYVDARVQP
CCCHHHHHHCCCEEE
9.7323663014
411PhosphotyrosineDARVQPIYGGTNEIM
CCCEEEEECCCHHHH
19.046877357

Disease-associated PTM Sites based on nsSNP

* Distance = the distance between SNP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SNP Related Disease Reference
329Phosphorylation333 (4)KQrs2286963Acylcarnitine levels: acylcarnitine measurement, blood metabolite measurement26068415
329Phosphorylation333 (4)KQrs2286963Metabolite levels: metabolite measurement20037589

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SYT2_HUMANSYT2physical
26186194
SYT2_HUMANSYT2physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
201475Acyl-CoA dehydrogenase very long-chain deficiency (ACADVLD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Related Literatures of Post-Translational Modification

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