ABI3_HUMAN - dbPTM
ABI3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABI3_HUMAN
UniProt AC Q9P2A4
Protein Name ABI gene family member 3
Gene Name ABI3
Organism Homo sapiens (Human).
Sequence Length 366
Subcellular Localization Cytoplasm . Colocalizes with PAK2 at leading edge of cells.
Protein Description May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility..
Protein Sequence MAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALASVAYQVGNLAGHTLRMLDLQGAALRQVEARVSTLGQMVNMHMEKVARREIGTLATVQRLPPGQKVIAPENLPPLTPYCRRPLNFGCLDDIGHGIKDLSTQLSRTGTLSRKSIKAPATPASATLGRPPRIPEPVHLPVVPDGRLSAASSAFSLASAGSAEGVGGAPTPKGQAAPPAPPLPSSLDPPPPPAAVEVFQRPPTLEELSPPPPDEELPLPLDLPPPPPLDGDELGLPPPPPGFGPDEPSWVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEGVSSEGTGFFPGNYVEPSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
134PhosphothreoninePENLPPLTPYCRRPL
CCCCCCCCCCCCCCC
20.2730803855
161PhosphoserineKDLSTQLSRTGTLSR
HHHHHHHHHCCCCCH
20.2723403867
163PhosphothreonineLSTQLSRTGTLSRKS
HHHHHHHCCCCCHHH
31.0123403867
165PhosphothreonineTQLSRTGTLSRKSIK
HHHHHCCCCCHHHCC
22.439873957
170PhosphoserineTGTLSRKSIKAPATP
CCCCCHHHCCCCCCC
28.369871865
210PhosphoserineSAASSAFSLASAGSA
HHHHHHHHHHHCCCC
23.8146108197
213PhosphoserineSSAFSLASAGSAEGV
HHHHHHHHCCCCCCC
38.1624275569
216PhosphoserineFSLASAGSAEGVGGA
HHHHHCCCCCCCCCC
23.9024275569
258PhosphothreonineEVFQRPPTLEELSPP
HHCCCCCCHHHHCCC
49.86118091
263PhosphoserinePPTLEELSPPPPDEE
CCCHHHHCCCCCCCC
38.3469013407
338PhosphothreonineEGTVICVTRRYSDGW
CCEEEEEEEECCCCC
12.6750558757
341PhosphotyrosineVICVTRRYSDGWCEG
EEEEEEECCCCCEEC
14.079510589
342PhosphoserineICVTRRYSDGWCEGV
EEEEEECCCCCEECC
28.0324275569
365PhosphoserinePGNYVEPSC------
CCCCCCCCC------
20.9650558763

Disease-associated PTM Sites based on nsSNP

* Distance = the distance between SNP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SNP Related Disease Reference
210Phosphorylation203;209 (7;1)SFrs616338
  • Alzheimer's disease (late onset):late-onset Alzheimers disease
28714976
213Phosphorylation203;209 (10;4)SFrs616338
  • Alzheimer's disease (late onset):late-onset Alzheimers disease
28714976
216Phosphorylation209 (7)SFrs616338
  • Alzheimer's disease (late onset):late-onset Alzheimers disease
28714976

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TARSH_HUMANABI3BPphysical
11501947
DTBP1_HUMANDTNBP1physical
16189514
CEP44_HUMANCEP44physical
16189514
PAK1_HUMANPAK1physical
11956071
PAK2_HUMANPAK2physical
11956071
ABI3_HUMANABI3physical
25416956
EVL_HUMANEVLphysical
25416956
ARMC7_HUMANARMC7physical
25416956
CEP44_HUMANCEP44physical
25416956
FBF1_HUMANFBF1physical
25416956
KLC4_HUMANKLC4physical
25416956
MR1L1_HUMANMRFAP1L1physical
25416956
KLC3_HUMANKLC3physical
25416956
ENAH_HUMANENAHphysical
17101133
WASF2_HUMANWASF2physical
17101133
WASP_HUMANWASphysical
21516116
NUP58_HUMANNUPL1physical
21516116

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Related Literatures of Post-Translational Modification

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